中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (34): 6393-6396.doi: 10.3969/j.issn.1673-8225.2010. 34.030

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

生物材料防粘连膜修复运动性肌腱断裂的特点及性能评价

郎明媚1，何玉龙1，吴  淼1，程  坤2，赵芸娜1   

  1. 河北建材职业技术学院，1体育教学部，2学生处，河北省秦皇岛市  066004
  • 出版日期:2010-08-20 发布日期:2010-08-20
  • 作者简介:郎明媚，女，1977年生，哈尔滨市人，汉族，2000年哈尔滨体育学毕业，讲师，主要从事体育教学与运动训练的研究。 mabaoling528@163.com

Characteristics and performance evaluation of anti-adhesion membrane for repair of exercise-induced tendon rupture

Lang Ming-mei1, He Yu-long1, Wu Miao1, Cheng Kun2, Zhao Yun-na1   

  1. 1 Department of Physical Education, 2 Students' Affairs Division, Hebei Vocational and Technical College of Building Materials, Qinhuangdao   066004, Hebei Province, China
  • Online:2010-08-20 Published:2010-08-20
  • About author:Lang Ming-mei, Lecturer, Department of Physical Education, Hebei Vocational and Technical College of Building Materials, Qinhuangdao 066004, Hebei Province, China mabaoling528@163.com

PDF

719

被引次数

20

摘要：

背景：总结修复肌腱断裂过程中预防肌腱粘连的研究进展，强调肌腱断裂的损伤类型，及修复肌腱断裂预防粘连所使用的防粘连膜的研究进展。
方法：以“肌腱断裂、肌腱粘连、防粘连膜”为中文关键词，以“tendon adhesion,absorbability antiseize continually membrane,Anti-adhesion membrane”为英文关键词，采用计算机检索中国期刊全文数据库、PubMed数据库1993-01/2010-03相关文章。纳入与有关修复肌腱断裂、预防肌腱粘连、生物膜等相关的文章；排除重复研究或Meta分析类文章。以18篇文献为主重点对修复运动性肌腱断裂防粘连膜的种类及其性能进行了讨论。
结果：计算机初检得到94篇文献，根据纳入排除标准，对药物薄膜、可吸收性防粘连膜、自体异体防粘连膜以及非生物防粘连膜对肌腱损伤导致的肌腱粘连的预防机制、作用原理进行分析。防粘连膜防治肌腱粘连一直是医学界普遍关注的问题。防粘连膜能促进内源性愈合，避免外源性愈合。防粘连膜种类繁多，其材料的成份、性质各有特点性能不同，防肌腱粘连的效果不同。
结论：防粘连膜通过薄膜的屏障作用防止或减轻粘连，药物薄膜通过药理作用影响肌腱愈合的内源性和外源性机制(主要加速内源性愈合)，达到减轻粘连的目的。可吸收防粘连膜可被机体吸收并排除体外，无毒及不良反应。

关键词: 肌腱粘连, 防粘连膜, 运动损伤, 肌腱断裂, 生物材料

Abstract:

OBJECTIVE: To summarize the research process of adhesion prevention during tendon rupture repair, to emphasize the injury type of tendon rupture, and to investigate anti-adhesion membranes for preventing tendon adhesions.
METHODS: Using “tendon rupture, tendon adhesion, anti-adhesion membrane” as the Chinese key words, “tendon adhesion, absorbability antiseize continually membrane, anti-adhesion membrane” as the English key words, a computer search of China Academic Journal Full-text database and PubMed database between January 1993 and March 2010 was performed. Articles related with the repair of tendon rupture, prevention of tendon adhesion, biofilm were included; repeated study or Meta analysis articles were excluded. Eighteen studies focused mainly on the type and performance of anti-adhesion membrane for the repair of exercise-induced tendon rupture.
RESULTS: Totally 94 literatures were primary screened out. According to inclusion and exclusion criteria, the prevention mechanism and action theory of drug film, absorbable anti-adhesion membrane, autologous and allogeneic anti-adhesion membrane, non-biological anti-adhesion membrane on the tendon adhesion resulted from tendon injury, were analyzed. Anti-adhesion membrane has always been an issue concerned the medical profession. Anti-adhesion membrane can promote endogenous healing and avoid exogenous healing. There is a wide range of anti-adhesion membrane, its composition and nature may be varied, as well as different performances of anti-adhesion.
CONCLUSION: The anti-adhesion membrane prevents or reduces the adhesion through barrier function of the film, drug films could reduce the adhesion by affecting tendon endogenous and exogenous healing (mainly endogenous healing), through the pharmacological effects. Absorbable membrane may be absorbed by the body and be excreted from the body, without toxicity or adverse reactions.

中图分类号: